Dynamic microPET imaging of ultrasound contrast agents and lipid delivery
نویسندگان
چکیده
منابع مشابه
Liposomes as ultrasound imaging contrast agents and as ultrasound-sensitive drug delivery agents.
Ultrasound imaging contrast agents that exhibit an affinity for specific tissue types, and especially, disease sites, would have considerable clinical value. Liposomal dispersions can be prepared such that they both reflect diagnostic ultrasound [1] and, when conjugated to an appropriate antibody, target themselves to thrombi in the vascular circulation [2]. The procedure for preparation of ult...
متن کاملEvolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery
Ultrasound (US) is one of the most frequently used diagnostic methods. It is a non-invasive, comparably inexpensive imaging method with a broad spectrum of applications, which can be increased even more by using bubbles as contrast agents (CAs). There are various different types of bubbles: filled with different gases, composed of soft- or hard-shell materials, and ranging in size from nano- to...
متن کاملGene delivery using ultrasound contrast agents.
With the human genome product and continuing advances in molecular biology many therapeutic genes have been discovered. In the cardiovascular system, gene therapy has the potential to improve myocardial vascularization and ameliorate congestive heart failure. For successful development of clinical gene therapy, however, effective gene delivery vectors are needed. Ultrasound contrast agents can ...
متن کاملHigh Framerate Imaging of Ultrasound Contrast Agents
Phospholipid-coated ultrasound contrast agents may deflate or even collapse because of stress resulting from ultrasound-induced oscillations. In this work we investigate the behavior of isolated contrast agent microbubbles during prolonged ultrasound excitation. Isolated microbubbles placed in a thin capillary tube were excited with hundreds of ultrasound pulses at a low mechanical index, and t...
متن کاملNonlinear dynamics of lipid-shelled ultrasound microbubble contrast agents
Encapsulated gas microbubbles, known as contrast agents, are widely used in ultrasound medical applications. The present study is devoted to modelling of the spatio-temporal dynamics of lipid-shelled contrast agents. A theoretical model is proposed that describes the radial and translational motion of a lipid-shelled microbubble in an ultrasound field. The model approximates the behaviour of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2008
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2008.07.030